Pa 10 Marichi, 2026, mankhwala atsopano a B7-H3-target antibody-drug conjugate (ADC) YL201 obayira jakisoni, omwe adapangidwa ndi MediLink Therapeutics, adapatsidwa Breakthrough Therapy Designation ndi Center for Drug Evaluation of China's National Medical Products Administration. Chizindikiro chomwe chaperekedwachi chikuphatikizidwa ndi Serplulimab pochiza khansa ya m'mapapo ya maselo ang'onoang'ono (ES-SCLC) yoyamba.
YL201 ndi ADC yatsopano yomwe imayang'ana kwambiri B7H3. Puloteni ya B7H3 imapezeka kwambiri pa maselo oopsa ndi maselo oyambitsa khansa amitundu yosiyanasiyana koma ili ndi mawonekedwe ochepa m'minofu yabwinobwino, zomwe zikuwonetsa kuthekera kwake ngati cholinga cha mankhwala a ADC. YL201 idapangidwa pogwiritsa ntchito ukadaulo wa MediLink wa Tumor Microenvironment Activable LINKer-payload (TMALIN®) wolumikizidwa ndi antibody yapadera ya B7H3. Pakadali pano, YL201 ikufufuzidwa m'matenda osiyanasiyana olimba ndipo yalowa mu mayeso ofunikira mu khansa ya m'mapapo ya maselo ang'onoang'ono ndi khansa ya m'mphuno ku China.
### Deta Yovomerezeka Yachipatala: Kugwira Ntchito Kwambiri Ndi Chitetezo Chabwino
Mu Marichi 2025, magazini yapamwamba yapadziko lonse lapansi ya *Nature Medicine* inafalitsa deta kuchokera ku mayeso azachipatala a Phase 1/1b a YL201 mwa odwala omwe ali ndi zotupa zolimba kwambiri. Kafukufukuyu, wophatikizapo odwala 312, adawonetsa:
- **Kugwira Ntchito Konse:** Pakati pa odwala 287 omwe adayesedwa, chiŵerengero cha mayankho olondola (ORR) chinali chochititsa chidwi cha 40.8%, kuphatikizapo odwala awiri omwe adayankha mokwanira (CR) ndi 115 omwe adayankha pang'ono (PR). Chiŵerengero cha kulamulira matenda (DCR) chinafika pa 83.6%.
- **Khansa Yaing'ono Yam'mapapo Yaikulu Kwambiri (ES-SCLC):** Mwa odwala omwe kale ankalandira chithandizo cha chemotherapy chochokera ku platinum, ORR inali 63.9%, DCR inali 91.7%, ndipo moyo wopanda progression (mPFS) unali miyezi 6.3.
- **Khansa ya m'mphuno (NPC):** Pakati pa odwala 70, ORR inali 48.6%, DCR inali 92.9%, ndipo odwala awiri analandira yankho lonse. Nthawi yapakati yolandira yankho (mDOR) inali miyezi 8.4.
Deta iyi ikutsimikizira mokwanira mphamvu yolimbana ndi chotupa komanso chitetezo cha YL201 pa mitundu yosiyanasiyana ya zotupa zolimba, zomwe zikuyika maziko olimba a kafukufuku wotsatira wazachipatala komanso kugwiritsa ntchito kwakukulu.
### Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology cha Beijing South Region: Mlatho Wanu Wopita ku Mankhwala Apadziko Lonse
Dipatimenti ya Chipatala cha Oncology ku Beijing South Region International imayesetsa nthawi zonse kuyambitsa njira zamakono zodziwira matenda a khansa komanso mankhwala. Timayang'anitsitsa momwe kafukufuku wamakono akuyendera komanso timasunga mgwirizano wamphamvu ndi mabungwe apamwamba asayansi mdziko muno komanso padziko lonse lapansi, kuyesetsa kupatsa odwala apadziko lonse mwayi wopeza chithandizo chamankhwala mwachangu kuphatikizapo YL201.
Gulu lathu la International Odwala Services lingakupatseni izi:
- **Kuyesa Kwachipatala Komwe Kumakuyenererani:** Gulu la akatswiri osiyanasiyana (MDT) lidzawunika mokwanira zolemba zanu zachipatala kuti lidziwe ngati chithandizo cha ADC chili choyenera matenda anu.
- **Kupeza Chisamaliro Chosavuta:** Thandizo lopeza ma visa opita ku China, kukonza nthawi yokambirana ndi akatswiri, kukonza mautumiki omasulira, ndikugwirizanitsa kulowa m'chipatala kuti mukhale ndi nthawi yopanda nkhawa.
### Lumikizanani nafe Tsopano kuti mudziwe zambiri
Ngati inu kapena wokondedwa wanu mukukumana ndi mavuto okhudzana ndi khansa ya m'mapapo ya maselo ang'onoang'ono, khansa ya m'mphuno, kapena zotupa zina zolimba, ndipo mukufuna kudziwa zambiri za chithandizo chamakono cha ADC kapena kuyesa mwayi wopeza chithandizo, chonde funsani Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region nthawi yomweyo. Akatswiri athu a International Patient Services adzayankha funso lanu mkati mwa maola 24.
**Zambiri zamalumikizidwe:**
- **Foni:** 400-880-3716���
- **WeChat:** 17801183037
- **Imelo:**
100085_010@163.com
myimmnet@163.com
Tikumvetsa kuti njira yochizira khansa ndi yovuta, koma kupambana kulikonse kumatanthauza chiyembekezo chatsopano. Dipatimenti ya Beijing South Region Oncology Hospital International ikufuna kukhala nanu, pogwiritsa ntchito ukadaulo waukadaulo wazachipatala komanso chisamaliro chachikondi, kuti tigonjetse khansa pamodzi ndikulandira chiyambi cha moyo.
Nthawi yotumizira: Marichi-24-2026