GT101 ndi chithandizo cha maselo odzipangira okha chomwe chimapangidwa ndi TIL yokulirapo komanso yokonzedwanso kuchokera ku chotupa cha wodwalayo. Chithandizochi chimaperekedwa posonkhanitsa minofu ya chotupa kuchokera kwa odwala ndikuchotsa TIL. TIL yochotsedwayo idzakulitsidwa pogwiritsa ntchito nsanja yopangira ya Grit Bio StemTexp® ndikuyiyikanso mwa odwala kuti amenyane ndi zotupa.
Pa 2024Msonkhano Wapachaka wa American Society of Clinical Oncology (ASCO),Zanenedwa za odwala 14 otupa olimba omwe adatenga nawo gawo mu kafukufuku wa GT101. Kuyesaku kudapangidwa ndi cholinga chachikulu chowunikira DLT ndikuwonetsa chitetezo cha GT101 mwa odwala otupa olimba omwe adayesedwa ndi kuchuluka kwa zochitika zoyipa za Giredi ≥ 3 (TEAEs). Zotsatira zachiwiri zinali zowunikira magawo ogwira ntchito kuphatikiza kuchuluka kwa mayankho onse (ORR), kuchuluka kwa kulamulira matenda (DCR), kupulumuka kosapitirira muyeso (PFS), nthawi yoyankhira (DOR), ndi kupulumuka konse (OS) malinga ndi RECIST v1.1.
Zotsatira: Pofika pa Novembala 10, 2023, gulu la odwala 14 linalandira chithandizo cha zaka zapakati pa 46.9 ndi pakati pa mizere 2.6 ya chithandizo chakale. Pambuyo pa chithandizo chokhazikika cha lymphodepletion chochokera ku FC, odwala adapatsidwa GT101 pa mlingo wa ≥ maselo 5×109 ndi mlingo wapakati wa maselo 3.7×1010, kutsatiridwa ndi IL-2 ya mlingo waukulu. Ambiri mwa ma AE omwe adawonedwa a Giredi ≥ 3 omwe anali ndi vuto la FC anali okhudzana ndi njira yochiritsira ya FC ndi IL-2, kuphatikiza kuchepa kwa kuchuluka kwa ma lymphocyte, kuchepa kwa kuchuluka kwa maselo oyera m'magazi, kuchepa kwa kuchuluka kwa ma neutrophil, kuchepa kwa magazi m'thupi, pyrexia ndi kuchepa kwa kuchuluka kwa ma platelet. Ambiri mwa ma AE awa adachira mkati mwa masiku 14, pomwe ochepa adatsitsidwa kufika pa Giredi 2 mkati mwa masabata 4. Pakati pa odwala 14 omwe adalembetsa pazizindikiro zosiyanasiyana (khansa ya maselo ang'onoang'ono-mapapo, melanoma, khansa ya pachibelekero), ORR inali 35.7%. Makamaka, mapointi 4 (28.6%) anali ndi yankho lotsimikizika la gawo (PR), pt imodzi (7.1%) idapeza yankho lathunthu (CR), ndipo mapointi 8 (57.1%) anali ndi matenda okhazikika (SD) ngati yankho lawo labwino kwambiri. pt imodzi inali ndi kupita patsogolo kwa matenda osatsimikizika (PD). Chodziwika bwino n'chakuti, pakati pa odwala 11/14 omwe ali ndi khansa ya pachibelekero, ORR inali 45.5% (5/11) ndi mapointi 4 (36.4%) omwe adakwanitsa PR ndi pt imodzi (9.1%) omwe adakwanitsa CR. Kuwongolera matenda kudawonedwa mu mapointi 10/11 (90.9%), ndipo PFS yapakati inali miyezi 4.2 ya gulu ili. Wodwala CR adatsatiridwa kwa nthawi yayitali ndipo nthawi ya CR ndi PFS (yoyerekezeredwa ndi Kaplan-Meier) inali masabata 24 ndi masabata 36, motsatana. Pambuyo pa kulowetsedwa kwa GT101, maselo a T adakula kwambiri m'magazi a odwala onse omwe ali ndi Tmax yapakati masiku 6.83 ndipo pafupifupi masiku 15.9.
Zomaliza: Mu kafukufuku wa GT101 Gawo 1, palibe ma SAE ndi DLT okhudzana ndi chithandizo omwe adawonedwa. Kwa odwala omwe ali ndi zotupa zoyamba kapena zotupa zolimba zomwe zidachiritsidwa kale, GT101 idawonetsa chitetezo chodalirika pansi pa njira yochizira lymphodepletion ndi IL-2 yochuluka komanso mbiri yabwino yachipatala, makamaka khansa ya pachibelekero, yokhala ndi ORR yolimbikitsa komanso nthawi yokwanira yoyankhira.
Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.
Nambala ya Foni: 4008803716
Email：myimmnet@163.com
Zolemba
1.https://www.grit-bio.com/newsinfo/4620292.html
2.https://ascopubs.org/doi/10.1200/JCO.2024.42.16_suppl.2548
Nthawi yotumizira: Disembala-20-2024