Pa February 10, 2025, CARsgen Therapeutics yalengeza kuti munthu woyamba kulandira chithandizo cha BCMA CAR-T chopangidwa pa nsanja ya THANK-u Plus™, wapeza yankho lokwanira (sCR) komanso negativity yochepa ya matenda otsalira (MRD) pa kuwunika kwa Tsiku la 28. Yopangidwa mkati, nsanja ya THANK-u Plus™ ndi ukadaulo watsopano wa CAR-T wopangidwa kuti uthetse mavuto opezeka mu chithandizo cha CAR-T.
Wodwalayo, yemwe adapezeka ndi matenda a myeloma wobwereranso/wosakhazikika, mtundu wa IgA-λ (R-ISS Stage II), adachitidwapo kale njira zitatu zochiritsira pamodzi ndi autologous hematopoietic stem cell transplantation. Pambuyo pa kupita patsogolo kwa matendawa pambuyo pa chithandizo chaposachedwa, wodwalayo adalembetsedwa mu mayeso azachipatala. Pambuyo polowetsedwa maselo a CAR T pamlingo wotsika kwambiri malinga ndi njira yachipatala, wodwalayo adakumana ndi vuto la kutulutsidwa kwa cytokine (CRS) la Giredi 1, lomwe lidathandizidwa bwino ndi mankhwala oletsa pyretics ndi tocilizumab, ndipo wodwalayo sanawonetse matenda a immunoeffector cell-associated neurotoxicity syndrome (ICANS) kapena zochitika zina zokhudzana ndi chitetezo chamthupi zokhudzana ndi CAR-T, zomwe zikuwonetsa chitetezo chabwino.
Chithandizo cha CAR-T ichi chapangidwa kuti chithandize kuchiza matenda a myeloma wobwerezabwereza/wosabwerezabwereza (R/R MM) ndi khansa ya m'magazi yobwerezabwereza/yosabwerezabwereza (R/R PCL). Zosintha zina zikuyembekezeka kuchitika mu theka lachiwiri la chaka chino.
Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.
Nambala ya Foni: 4008803716
Email：myimmnet@163.com
Zolemba
2.https://www.prnasia.com/
Nthawi yotumizira: Feb-11-2025