Sevabertinib Yavomerezedwa ku China: Chithandizo Chatsopano Cholondola cha HER2-Mutant NSCLC

Posachedwapa, Bayer adalengeza kuti bungwe la National Medical Products Administration (NMPA) la ku China lavomereza mankhwala atsopano otchedwa sevabertinib ochizira odwala akuluakulu omwe ali ndi khansa ya m'mapapo yomwe siingathe kuchiritsidwa m'deralo kapena yofalikira m'maselo ang'onoang'ono (NSCLC) omwe ali ndi kusintha kwa HER2 (ERBB2) ndipo adakumana ndi matenda atalandira chithandizo chimodzi cham'mbuyomu.

Izi zikutanthauza kuti mosasamala kanthu kuti mukuchokera kudziko liti, tsopano mutha kupeza chithandizo chapamwamba kwambiri padziko lonse lapansi kudzera mu Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.

Sevabertinib: Kuwongolera Mwachindunji Kusintha kwa HER2

Sevabertinib ndi mankhwala atsopano, opangidwa pakamwa, komanso osinthika a tyrosine kinase inhibitor. Amaletsa mwamphamvu HER2 yosinthika (kuphatikiza HER2 exon 20 insertions ndi point mutations) komanso EGFR. Poyerekeza ndi ma TKI achikhalidwe osasinthika, TKI yosinthika imapereka kutsekeka kwakanthawi komanso kolondola kwa cholinga, zomwe zimathandiza kuti chithandizo chizilamuliridwa bwino komanso kuchepetsa zotsatirapo zake kwa nthawi yayitali.

Kulimbikitsa Deta Yachipatala: Mayankho Ofunika, Ubwino Wokhalitsa

Kuvomerezedwa kwa sevabertinib kumachokera ku zotsatira zabwino kuchokera ku mayeso apadziko lonse a Phase I/II SOHO-01:

- Kwa odwala omwe sanalandirepo chithandizo cha ADC cholunjika ku HER2

Chiŵerengero cha mayankho olondola (ORR) chinafika pa 64%, kuphatikizapo mayankho onse a 2.5% ndi mayankho osakwanira a 62%. Nthawi yapakati ya mayankho inali miyezi 9.2.

- Kwa odwala omwe adalandira kale chithandizo cha ADC cholunjika ku HER2

ORR inali idakali 38%, kuphatikizapo mayankho onse 5.5% ndi mayankho ochepa 33%. Nthawi yapakati yoyankha inali miyezi 7.

Mbiri ya chitetezo ndi yodalirika komanso yogwirizana ndi malipoti am'mbuyomu, zomwe zimapangitsa kuti pakhale maziko odalirika a chithandizo cha nthawi yayitali.

N’chifukwa Chiyani Muyenera Kusankha Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region?

Monga malo azachipatala apadziko lonse lapansi omwe amayang'ana kwambiri chisamaliro cha khansa molondola, timapereka odwala padziko lonse lapansi:

- Gulu lachipatala la zilankhulo zambiri: Utumiki mu Chitchaina, Chingerezi, Chirasha, Chiarabu, ndi zina zambiri, kuonetsetsa kuti kulankhulana kulikonse kuli bwino.

- Ntchito zoperekedwa kwa odwala padziko lonse lapansi: Kugwirizana kodzipereka kuyambira paupangiri wakutali ndi chithandizo cha visa yachipatala mpaka kusamutsidwa kupita ku eyapoti, kukonzekera kugonekedwa kuchipatala, ndi kutsatira pambuyo pa chithandizo.

- Mapulani a chithandizo chapadera: Chithandizo chokonzedwa bwino komanso mapulani osamalira odwala molingana ndi majini a wodwalayo komanso momwe alili.

Lumikizanani Nafe Lero Kuti Muyambe Ulendo Wanu wa Chiyembekezo

Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region

Nambala Yothandizira Odwala Padziko Lonse: 400-880-3716

WeChat: 17801183037

Imelo:

- 100085_010@163.com

- myimmnet@163.com

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Moyo Wanu Uyenera Chithandizo Chabwino Kwambiri

Kaya mukufuna njira yoyamba yopezera chiyembekezo kapena mwapita kale patsogolo mutalandira mankhwala ambiri omwe adaperekedwa kale, sevabertinib ikhoza kukhala njira yosinthira kwambiri. Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region yakonzeka kukutsegulirani njira yobiriwira—imbani 400-880-3716 tsopano, kapena titumizireni imelo kudzera pa WeChat kapena imelo. Tiloleni tikuthandizeni kulumikizana ndi akatswiri otsogola, kuwunika kuyenerera, ndikukonzekera ulendo wanu wopeza chithandizo ku China.

Musadikire. Kuyimba kulikonse kungakhale chiyambi chatsopano.

Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region — Kugwirizanitsa Odwala Padziko Lonse ndi Mankhwala Olondola a ku China.