Bambo X ndi wodwala wazaka za m'ma 40 yemwe adapezeka ndi acral melanoma. Atachitidwa opaleshoni yayikulu atapezeka kuti ali ndi matenda mu 2015, matenda ake adakhalabe olimba kwa zaka zisanu ndi zinayi. Mwatsoka, pafupifupi chaka chapitacho, matenda ake adabwereranso ndi metastases m'mapapu onse awiri. Ngakhale adalandira chithandizo cha inguinal ndi pelvic lymph node komanso chithandizo chachitatu cha systemic (kuphatikizapo chithandizo cha PD-1 antibody ndi NRAS mutation-target therapy), zotupazo zidakhudza kwambiri mapapo onse, chiuno, minofu ya pansi pa mimba ya kumanja, ndi minofu ya bilateral erector spinae, zomwe zidapangitsa kuti munthu amve kupweteka kwambiri komanso moyo wake ukhale wochepa kwambiri.
Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.
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Kumayambiriro kwa chaka cha 2025, a X adatenga nawo gawo mu mayeso azachipatala a chithandizo cha maselo a TIL (GC101) ndipo adamaliza kumwa mankhwala a TIL cell kumayambiriro kwa mwezi wa June. Ngakhale kuti chotupa chake chinali cholemera, ndipo chilonda chachikulu kwambiri chinali 62 mm, milungu isanu ndi umodzi atamwa mankhwalawo, zilonda zake zonse zinachepa ndi 31.9%, ndipo chilonda chachikulu kwambiri chinachepa ndi pafupifupi 40%. Mphamvu yonse ya chithandizo idafika pagawo la yankho (PR). Chofunika kwambiri, a X sanakumane ndi zotsatirapo zoyipa zilizonse atamwa mankhwala a GC101 TIL, koma zotsatirapo zoyipa zomwe zimayambitsidwa ndi chitetezo chamthupi monga kuzizira ndi malungo, zomwe zinatha mwachangu ndi chithandizo cha zizindikiro.
Zokhudza GC101
GC101 ndi mankhwala achilengedwe a TIL TIL omwe adapangidwa pogwiritsa ntchito nsanja yokulitsa maselo ya Juncell Therapeutics ya DeepTIL®. DeepTIL® imalola ma TIL kukhala amphamvu mokwanira kotero kuti palibe kuphatikiza kwa IL-2 komwe kudzafunike pambuyo polowetsedwa, ndipo mphamvu ya chithandizo chisanachitike ikhoza kukhala yotsika.
Monga chithandizo choyamba cha TIL chomwe chimangofunika chithandizo chocheperako komanso chosagwiritsa ntchito jakisoni wa IL-2 padziko lonse lapansi, GC101 yatsimikiziridwa chifukwa cha kugwira ntchito bwino komanso chitetezo chake chomwe chimakweza kwambiri chitetezo ndi kupezeka kwa chithandizo cha TIL.
Zokhudza Melanoma
Ku China, chiwerengero cha anthu omwe amafa ndi khansa ya melanoma chili pamwamba ndipo chiwerengero cha anthu omwe amafa chikukwera chaka ndi chaka. Poyerekeza ndi anthu aku Europe kapena aku America, pali kusiyana kwakukulu pa makhalidwe a khansa ya melanoma m'Chitchaina: pafupifupi 90% ya khansa ya melanoma imachokera pakhungu pakati pa anthu aku Europe ndi America. Ku Asia, pafupifupi 50% ya khansa ya melanoma imachokera ku malekezero ndi 20-30% mu nembanemba ya mucous. Mosiyana ndi zimenezi, khansa ya malekezero ndi mucous membrane ya mtundu wa khansa ya melanoma ili ndi chiopsezo choyipa kwambiri.
Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.
Nambala ya Foni: 4008803716
Chizindikiro cha WeChat: 17801183037
Email：myimmnet@163.com
Nthawi yotumizira: Ogasiti-07-2025