Deta Yoyambirira ya Zachipatala ya Allogeneic BCMA CAR-T CT0596, Yosonyeza Chitetezo Chabwino ndi Kugwira Ntchito

Pa Meyi 12, 2025, CARsgen yalengeza zambiri zoyambirira zachipatala za CT0596, CAR-T yolumikizidwa ndi BCMA yopangidwa pogwiritsa ntchito nsanja ya THANK-u Plus™. CT0596 ikuwunikidwa mu kafukufuku woyambirira wazachipatala wofufuza za relapse/refractory multiple myeloma (R/R MM) kapena relapse/refractory plasma cell leukemia (R/R PCL) kuti awone chitetezo chake, komanso momwe zimagwirira ntchito poyamba.

Pofika pa Meyi 6, 2025, odwala 8 omwe ali ndi R/R MM omwe adalandira njira zitatu zochiritsira kale adalembedwa ndikupatsidwa CT0596 pambuyo pa lymphodepletion ndi regimen ya FC (fludarabine 22.5-30 mg/m² ndi cyclophosphamide 350-500 mg/m²). Zomwe zapezeka kuyambira miyezi inayi yotsatira ndi izi:

Palibe poizoni woletsa mlingo (DLTs), ≥Giredi 3 cytokine release syndrome (CRS), immuno effector cell-associated neurotoxicity syndrome (ICANS), kapena graft-versus-host disease (GVHD) zomwe zanenedwa. Mankhwalawa anali otetezeka, ndipo palibe odwala omwe anasiya kulandira chithandizo chifukwa cha zovuta zina.

1) Pakati pa odwala 5 omwe adamaliza kuyesa koyamba kwa mphamvu pa Sabata lachinayi, odwala atatu (60%) adapeza yankho lokwanira/yankho lokwanira (sCR/CR), ndipo odwala anayi (80%) adapeza matenda ochepa otsalira (MRD) - negativity mu bone morrow. 2) Deta yoyambirira ya mphamvu kuchokera kwa odwala awiri pa Tsiku la 14 idawonetsa kuchepa kwa zilonda zoyezeka ndi ≥92% ndi ≥65%, motsatana. 3) Wodwala m'modzi anali asanafikire nthawi yowunikira mphamvu yomwe idakhazikitsidwa ndi protocol.

Odwala onse a sCR/CR adapitilizabe kulandira chithandizo, kuphatikizapo wodwala woyamba amene adamaliza kutsatira kwa miyezi inayi.

Kutengera ndi deta yoyambirira yachitetezo ndi mphamvu yake, CT0596 yawonetsa kulekerera bwino komanso kulimbikitsa zizindikiro zogwira ntchito mwa odwala a R/R MM pamlingo wonse wodziwika bwino wa mlingo, ndipo kuwonjezeka kwa CAR-T kwawonedwa. Zomwe zapezekazi zikuyenera kufufuzidwa kwambiri osati mu R/R MM yokha, komanso m'matenda ena a khansa ya m'magazi ndi matenda a autoimmune omwe amayamba chifukwa cha maselo a plasma omwe amagwira ntchito okha.

Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.

Nambala ya Foni: 4008803716

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