Pembrolizumab Yavomerezedwa ku China kuti igwiritsidwe ntchito ndi HCC yosagwiritsidwa ntchito pochiza matenda a shuga pamodzi ndi Lenvatinib ndi TACE

Posachedwapa, Merck & Co., Inc. (Merck) yalengeza kuti mankhwala ake oletsa PD-1, pembrolizumab, avomerezedwa ndi National Medical Products Administration (NMPA) ku China kuti agwiritsidwe ntchito limodzi ndi lenvatinib ndi transarterial chemoembolization (TACE) pochiza odwala omwe ali ndi khansa ya chiwindi yosasinthika komanso yosafalikira.

Kuvomerezedwa kwa chizindikiro chatsopanochi kumachokera ku deta yochokera ku kafukufuku wachipatala wa Gawo III la LEAP-012. Mu kafukufuku wa Gawo III wokhudza malo ambiri, wosasankhidwa mwachisawawa, komanso wosawona mbali zonse ziwiri (LEAP-012), odwala 480 adalembedwa ndipo adapatsidwa mwachisawawa kuti alandire lenvatinib kuphatikiza TACE kuphatikiza pembrolizumab (n=237) kapena TACE kuphatikiza dual placebo (n=243).

Zotsatira zake zinasonyeza kuti moyo wapakati wopanda progression (PFS) unali miyezi 14.6 mu gulu la lenvatinib kuphatikiza TACE kuphatikiza pembrolizumab, poyerekeza ndi miyezi 10.0 mu gulu la placebo. Chiwerengero cha moyo wonse wa miyezi 24 (OS) chinali 75% ndi 69%, motsatana.

Lenvatinibndi mankhwala oletsa kinase omwe amagwiritsidwa ntchito pochiza mitundu ina ya khansa. Mankhwala oletsa kinase ndi mankhwala oletsa ma enzyme omwe amaletsa kugwira ntchito kwa protein kinase imodzi kapena zingapo.

Pembrolizumab ndi antibody ya monoclonal IgG4 kappa yomwe imayendetsedwa motsutsana ndi pamwamba pa maselo a anthu PD-1 (programmed death receptor-1) pa ma lymphocytes. Cholandira cha PD-1 chimapereka "malo ofunikira otetezera chitetezo chamthupi," omwe amathandiza kuti chitetezo chamthupi chisadziukire chokha. Mitundu ina ya zotupa imakhala ndi mawonekedwe apamwamba a PD-L1 (programmed death receptor ligand-1). Mitundu ina ya zotupa imagwiritsa ntchito chitetezo chamthupi chosinthika komwe imatenga physiology yachilengedwe ya PD-L1 induction (kuteteza kuwonongeka kwa chitetezo chamthupi kuchokera ku matenda) ndikuyisintha kuti ikhale ndi mayankho otsutsana ndi chotupa. PD-L1 ikagwira ntchito ndi PD-1, ntchito ya T-cell imalepheretsedwa; pembrolizumab imaletsa mapangidwe a PD-1: PDL-1 complex omwe amalola kupha bwino kwa T-cell.

Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.

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