Pa Meyi 1, 2025, Hansoh Pharmaceutical yalengeza kuti mankhwala a B7-H4-target antibody-drug conjugate (ADC) HS-20089 omwe adadzipangira okha kuti agwiritsidwe ntchito jakisoni avomerezedwa kuti aphatikizidwe ngati mankhwala opangidwa ndi Breakthrough-Therapy ndi National Medical Products Administration (NMPA) ya ku China, ndi chizindikiro chomwe chikuperekedwa kwa odwala khansa ya m'mimba yobwerezabwereza, khansa ya m'mimba kapena khansa ya m'mimba yoyambirira.
Kusankhidwa kumeneku kumathandizidwa ndi zotsatira za kafukufuku wa Gawo I HS-20089-101 ndi kafukufuku wa Gawo II HS-20089-201. Kafukufuku wa HS-20089-101 ndi mayeso azachipatala a Gawo I okhala ndi malo ambiri, otseguka kuti awone chitetezo, kulekerera, mankhwala, ndi kugwira ntchito kwa HS-20089 pobayira odwala omwe ali ndi zotupa zolimba kwambiri. Kafukufuku wa HS-20089-201 ndi mayeso azachipatala a Gawo II okhala ndi malo ambiri, otseguka kuti awone mphamvu, chitetezo, mbiri ya mankhwala, ndi chitetezo cha mthupi cha HS-20089 m'mitsempha mwa odwala omwe ali ndi khansa ya ovary yobwerezabwereza kapena yofalikira komanso khansa ya endometrial.
HS-20089 ndi ADC yolimbana ndi B7-H4 yokhala ndi topoisomerase inhibitor (TOPOi) yomwe ikupangidwa kuti igwiritsidwe ntchito pochiza khansa ya m'chiberekero ndi zotupa zina za amayi m'mayesero ambiri azachipatala ku China, ndipo gawo lalikulu kwambiri lofufuza ndi mayeso azachipatala a Gawo III. B7-H4 ndi glycoprotein yoteteza chitetezo chamthupi yomwe imapezeka kwambiri m'zotupa zambiri zolimba, kuphatikizapo khansa ya endometrial ndi khansa ya m'chiberekero, koma yokhala ndi mawonekedwe ochepa m'maselo abwinobwino.
Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.
Nambala ya Foni: 4008803716
Imelo：myimmnet@163.com
Nthawi yotumizira: Meyi-09-2025