Lynparza Yophatikizidwa ndi Abiraterone ndi Prednisolone Yavomerezedwa ku China kwa Odwala a mCRPC Omwe Ali ndi BRCA-Mutated

Pa Julayi 31, AstraZeneca ndi Merck & Co. adalengeza pamodzi kuti mankhwala awo oletsa PARP a Lynparza, pamodzi ndi Abiraterone ndi prednisolone, avomerezedwa ku China kuti azichiza odwala akuluakulu omwe ali ndi khansa ya prostate yolimbana ndi metastatic castration (mCRPC) omwe ali ndi ma germline kapena somatic BRCA mutations (gBRCAm kapena sBRCAm).

Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.

Nambala ya Foni: 4008803716

Chizindikiro cha WeChat: 17801183037

Imelo：myimmnet@163.com

Lynparza (olaparib) ndi mankhwala oyamba oletsa PARP komanso mankhwala oyamba oletsa kuwonongeka kwa DNA (DDR) m'maselo/zotupa zomwe zili ndi vuto la HRR, monga kusintha kwa BRCA1 ndi/kapena BRCA2. Kuletsa PARP ndi Lynparza kumabweretsa kutsekeka kwa PARP yolumikizidwa ku kusweka kwa DNA, kuchedwa kwa mafoloko obwerezabwereza, kugwa kwawo komanso kupanga kusweka kwa DNA kawiri komanso kufa kwa maselo a khansa.

Kuvomerezedwa kumeneku kunachokera makamaka ku zotsatira za kusanthula kwa magulu ang'onoang'ono kuchokera ku magulu apadziko lonse lapansi ndi aku China a mayeso a PROpel Phase III. PROpel ndi mayeso azachipatala a Phase III omwe amachitidwa mwachisawawa, osawona mbali ziwiri, omwe ali ndi malo ambiri owunikira momwe Lynparza imagwirira ntchito limodzi ndi Abiraterone ndi prednisolone poyerekeza ndi placebo pamodzi ndi Abiraterone ndi prednisolone mwa odwala aamuna omwe ali ndi mCRPC omwe sanalandirepo chemotherapy kapena novel hormonal therapy (NHA) pa siteji ya mCRPC.

Deta yochokera ku gulu la odwala padziko lonse lapansi omwe ali ndi kusintha kwa BRCA inasonyeza kuti Lynparza pamodzi ndi Abiraterone inasonyeza kusintha kwakukulu pa kupulumuka kosasinthika kwa radiographic (rPFS) poyerekeza ndi Abiraterone monotherapy. Kusanthula kwa magulu ang'onoang'ono a odwala omwe ali ndi kusintha kwa BRCA m'gulu lapadziko lonse lapansi kunawonetsa kuti Lynparza pamodzi ndi Abiraterone kunachepetsa chiopsezo cha kupita patsogolo kwa matenda kapena imfa ndi 76% ndi chiopsezo cha imfa ndi 70%. RPFS yapakati ndi kupulumuka kwapakati (OS) m'gulu la Lynparza kuphatikiza Abiraterone sizinafikebe, pomwe rPFS yapakati ndi OS yapakati m'gulu la Abiraterone monotherapy zinali miyezi 8 ndi miyezi 23, motsatana.

Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.

Nambala ya Foni: 4008803716

Chizindikiro cha WeChat: 17801183037

Email：myimmnet@163.com