Pa Julayi 31, 2025, ImmuneOnco Biopharmaceuticals yalengeza za chitetezo ndi mphamvu yoyambirira kuchokera ku kafukufuku wa IMM2510 wa Gawo 2 wotseguka, wophatikizapo chemotherapy kwa odwala omwe ali ndi khansa ya m'mapapo ya non-small cell (NSCLC) yomwe idachitika ku China.
Pofika pa Julayi 1, 2025, odwala 33 adapatsidwa mlingo wa 10 mg/kg, ndipo odwala 21 adayesedwa kamodzi kokha ka chotupa (komwe kungayesedwe). Mayankho ochepa adawonedwa mwa 62% ya odwala omwe adayesedwa bwino, kuphatikiza mayankho ochepa mwa 80% (8/10) ya odwala omwe ali ndi squamous NSCLC ndi 46% (5/11) ya odwala omwe alibe squamous NSCLC. Odwala ambiri omwe adayesedwa bwino adayesedwa kamodzi kokha ka chotupa pa nthawi yomaliza deta. ImmuneOnco ikuyembekeza kupereka deta yachitetezo ndi yogwira ntchito mu mayeso ophatikizana a chemotherapy a IMM2510 ku NSCLC yakutsogolo pamsonkhano wachipatala wamtsogolo.
Mbiri ya chitetezo cha IMM2510 imathandizira chitukuko china chachipatala, popanda poizoni wochepetsa mlingo womwe unawonedwa mwa odwala 33 omwe anali ndi chitetezo. Mwa odwala awa, panalibe zochitika zoyipa zokhudzana ndi chithandizo (TRAE) zomwe zinapangitsa kuti mlingo uchepe kapena kufa, ndipo TRAE imodzi yokha inapangitsa kuti mankhwala asiye kugwiritsidwa ntchito. Ma TRAE ofala kwambiri a Giredi 3+ anali a hematologic, omwe anali ndi zotsatira zosazolowereka zachipatala. Zochitika zoyipa zomwe nthawi zambiri zimagwirizanitsidwa ndi kuletsa kwa VEGF (monga kuthamanga kwa magazi, proteinuria, hemoptysis) ndi zochitika zoyipa zokhudzana ndi chitetezo chamthupi sizinali zachilendo ndipo nthawi zambiri zinali zochepa, ndipo zochita zokhudzana ndi kulowetsedwa zinali pafupifupi zochepa.
Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.
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Nthawi yotumizira: Ogasiti-05-2025