Mapiritsi a Glecirasib Citrate Avomerezedwa Kuti Ayambe Kugulitsidwa, Akutsegula Mutu Watsopano mu Chithandizo cha KRASG12C Chosinthidwa Kwambiri cha NSCLC

Pa Meyi 22, 2025, Allist Pharmaceuticals idalengeza kuti mankhwala ake atsopano a Airuikai (Glecirasib Citrate Tablets), choletsa cha KRAS-G12C, avomerezedwa mwalamulo kuti ayambe kugwiritsidwa ntchito pamsika ndi National Medical Products Administration (NMPA). Chivomerezochi chimalola Airuikai kugwiritsidwa ntchito pochiza odwala akuluakulu omwe ali ndi khansa ya m'mapapo ya KRAS®®G12C yomwe idasinthidwa kale (NSCLC) omwe adalandirapo chithandizo chamankhwala chamthupi chimodzi. Izi zikutanthauza chithandizo china chatsopano cha khansa ya m'mapapo chomwe chavomerezedwa ndi Allist Pharmaceuticals, chopereka njira yatsopano yothandizira odwala omwe ali ndi khansa ya m'mapapo ya KRASG12C yomwe idasinthidwa (NSCLC) ndikuthandizira kusintha mawonekedwe a chithandizo cha khansa yovuta kuchiza iyi.

Kuvomerezedwa kumeneku kumachokera ku zotsatira za kafukufuku wofunikira wa Gawo Lachiwiri lofufuza za chitetezo, kulekerera, komanso kugwira ntchito kwa Glecirasib monotherapy mwa odwala omwe ali ndi khansa ya m'mapapo yopanda maselo ang'onoang'ono omwe ali ndi kusintha kwa KRASG12C omwe adalephera kapena osalolera chithandizo chokhazikika.

Zotsatira zake zasonyeza kuti Goleresai ndi yothandiza komanso yolekerera bwino. Pofika pa Seputembala 28, 2024, odwala 119 a NSCLC adaphatikizidwa mu kusanthulaku. Chiwerengero chotsimikizika cha yankho lolondola (cORR), monga momwe adawunikira ndi Independent Review Committee (IRC), chinali 49.6% (40.2%-59.0%), ndi chiwerengero chowongolera matenda (DCR) cha 86.3% (78.7%-92.0%). Nthawi yapakati yoyankha (DOR) inali miyezi 14.5 (miyezi 9.6 mpaka yosayerekezeka), kupulumuka kwapakati kopanda kupita patsogolo (PFS) kunali miyezi 8.2 (5.2–11.1), ndipo kupulumuka kwapakati konse (OS) kunali miyezi 17.5 (miyezi 13.6 mpaka yosayerekezeka).

Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.

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