Pa 31 Marichi, 2026, Center for Drug Evaluation of China's National Medical Products Administration idapereka nkhani yosangalatsa: GFH375, yopangidwa ndi GenFleet Therapeutics, yaphatikizidwa mwalamulo ngati "Breakthrough Therapy" yochizira odwala omwe ali ndi khansa ya kapamba yomwe ili ndi kusintha kwa KRAS G12D omwe adalandira chithandizo chimodzi cham'mbuyomu. Izi zikuwonetsa kupita patsogolo kofunikira kwambiri pankhani yochizira khansa ya kapamba molondola.
Ngati inu kapena wokondedwa wanu mukuvutika ndi khansa ya kapamba ya KRAS G12D yosinthika kwambiri, musataye mtima. Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region (400-880-3716) ikutsatira bwino chitukuko chamakonochi ndipo imapereka upangiri waukadaulo komanso ntchito zogwirizanitsa chithandizo kwa odwala ochokera kumayiko ena.
**Zokhudza GFH375/VS-7375**
GFH375 ndi mankhwala oletsa ang'onoang'ono a KRAS G12D (ON/OFF) omwe amapangidwa kuti azitha kusinthana kwa GTP/GDP, motero amalepheretsa kuyambika kwa njira yotsikira komanso kuletsa kuchulukana kwa maselo a chotupa. Kafukufuku woyambirira adawonetsa kuletsa kutengera mlingo m'mamodeli omwe ali ndi kusintha kwa KRAS G12D; GFH375 idawonetsanso chiopsezo chochepa pakusankha kwa kinase ndi mayeso achitetezo.
GenFleet idalowa mgwirizano wopeza ndi kupanga ndi Verastem Oncology (Nasdaq: VSTM) kuti ipititse patsogolo mapulogalamu atatu atsopano a khansa okhudzana ndi khansa yoyendetsedwa ndi RAS/MAPK. Mgwirizanowu umapatsa Verastem mwayi wapadera wopeza chilolezo cha mankhwala atatuwa atatha kumaliza bwino zochitika zomwe zidakonzedweratu mu kuyesa kwa Gawo Loyamba. Mu Disembala 2023, Verastem idasankha GFH375/VS-7375, choletsa cha KRAS G12D (ON/OFF) chomwa, ngati pulogalamu yake yotsogola kuchokera ku mgwirizanowu, ndipo chilolezo cha GFH375 chomwe chidachitika mu Januwale 2025 chinali choyamba kuchokera ku mgwirizanowu. Malayisensiwa amapatsa Verastem ufulu wokonza ndi kugulitsa kunja kwa China, pomwe GenFleet imasunga ufulu mkati mwa China.
**Deta yodalirika yoyesera zachipatala ya Gawo Loyamba/Lachiwiri yomwe idaperekedwa ku Msonkhano wa ESMO wa 2025:**
- 91.5% ya odwala adachepetsa zilonda zomwe adazifuna
- Chiŵerengero cha mayankho olondola (ORR) chafika pa 40.7%
- Chiŵerengero cha matenda (DCR) chinali chokwera kufika pa 96.7%
- Kupulumuka kwapakati kopanda kupita patsogolo (mPFS) kunali miyezi 5.52
- Kupulumuka kwa miyezi 4 popanda kupita patsogolo kunali 78.2%
Deta iyi, yochokera kwa odwala 59 omwe ali ndi KRAS G12D-mutant pancreatic ductal adenocarcinoma (PDAC) yapamwamba omwe adalandira chithandizo cham'mbuyomu, ikuwonetsa bwino momwe GFH375 imagwirira ntchito polimbana ndi chotupa mu khansa ya pancreatic yokana.
**N’chifukwa Chiyani Muyenera Kusankha Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region?**
Monga mtsogoleri wa ntchito zachipatala zapadziko lonse lapansi, Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region yadzipereka kupereka odwala apadziko lonse lapansi:
- Upangiri wa akatswiri azachipatala ndi mautumiki okumana ndi anthu m'zilankhulo zambiri
- Kupeza akatswiri otsogola a khansa ku China komanso padziko lonse lapansi
- Njira imodzi yopezera chithandizo chamankhwala chodutsa malire
Tikumvetsa kuti kwa odwala khansa yoopsa, tsiku lililonse lowonjezera lodikira limabweretsa chiopsezo chachikulu. Chifukwa chake, takhazikitsa njira zingapo zosavuta zolumikizirana ndi mayiko ena kuti tiwonetsetse kuti mukulandira chithandizo cha akatswiri panthawi yake.
**Lumikizanani nafe lero ndikuyamba ulendo wanu wa chiyembekezo**
���� Nambala ya foni: 400-880-3716
���� WeChat: 17801183037
���� Imelo:
- 100085_010@163.com
- myimmnet@163.com
Kaya muli m'dziko kapena dera liti, kapena njira zingati zochiritsira zomwe mwayesa kale, Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing ili okonzeka kukuthandizani polimbana ndi khansa. Kupita patsogolo kwa GFH375 kungakhale kuwala komwe mwakhala mukuyembekezera.
Call 400-880-3716, add us on WeChat at 17801183037, or email us at 100085_010@163.com or myimmnet@163.com.
Tiyeni tonse pamodzi tilimbikire kupeza mwayi wochuluka pa moyo.
> Dziwani: GFH375 sinavomerezedwe mwalamulo kuti igulitsidwe ku China. Kusankhidwa kwake kwa Breakthrough Therapy kukuyembekezeka kuti kufulumizitse kupezeka kwa mankhwala kuchipatala. Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region idzayang'anira bwino kupita patsogolo kwa kupezeka kwa mankhwala ndikupereka chidziwitso cha chithandizo chamakono komanso ntchito zogwirizanitsa odwala oyenerera. Chonde tsatirani malangizo a dokotala wanu okhudza mapulani enaake a chithandizo.
Nthawi yotumizira: Epulo-10-2026