Posachedwapa, wodwala khansa ya kapamba yomwe inali italephera kulandira chithandizo chamankhwala kangapo kale inachepa kwambiri atalandira chithandizo cha maselo a KD-496 CAR-T, ndipo chikhululukirocho chinatsimikizika patatha masiku 180 kuchokera pamene adalandira chithandizo.
Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.
Nambala ya Foni: 4008803716
Chizindikiro cha WeChat: 17801183037
Imelo：myimmnet@163.com
Wodwalayo, mkazi wazaka 73, adapezeka mu Julayi 2021 ndi mutu wa kapamba womwe unatsekeka pang'ono ndi ndulu. Anachitidwa opaleshoni ya duodenectomy, pomwe kulemera kolimba pafupifupi 3 cm kudapezeka panthawi yomwe mutu wa kapamba unkatuluka. Kuwunika kwa matenda kunatsimikizira kuti adenocarcinoma inali yosiyana pang'ono. Pambuyo pa opaleshoni, adalandira paclitaxel (nab-paclitaxel) yolumikizidwa ndi albumin pamodzi ndi mankhwala a S-1, kutsatiridwa ndi M108 + nab-paclitaxel + gemcitabine ndi LM108 pamodzi ndi toripalimab. Anali ndi mbiri ya schizophrenia ndi matenda a shuga, onse awiri akulamulidwa bwino ndi mankhwala.
Mu February 2025, wodwalayo adalandira chithandizo cha maselo a KD-496 CAR-T. Pa nthawi yoyamba yoyezetsa chotupa patatha milungu inayi, ngakhale kuti anali wokalamba komanso anali ndi chotupa chochuluka (chotupa choyambirira cha 58 mm), chotupa chomwe chinali pachiwopsezo chinali chitachepa ndi 34.5% poyerekeza ndi choyambira. Pofika tsiku la 60, chotupacho chinali chitachepa ndi 37.9%, ndipo pofika masiku 90 ndi 180, chotupacho chinapitirira kuchepa ndi 44.8%, kusunga gawo la yankho (PR) popanda poizoni wambiri m'mimba kapena m'mitsempha.
Wodwala khansa ya m'mimba wazaka 70 adachitidwa opaleshoni mu February 2023, pomwe matenda a pambuyo pa opaleshoni adawonetsa adenocarcinoma yomwe inali itayamba kale kufalikira ku ma lymph nodes, peritoneum, ndi mapapo onse awiri, limodzi ndi ascites ndi pleural effusion (matenda apamwamba komanso ofala kwambiri). Masabata asanu ndi atatu atachitidwa opaleshoni, adalandira SOX chemotherapy (oxaliplatin + S-1), koma vuto lake lidapita patsogolo. Kuyesa kotsatira ndi PX (paclitaxel) + PD-1 (immunotherapy) kwa nthawi zinayi, kutsatiridwa ndi capecitabine + nivolumab, nakonso sikunalepheretse kupita patsogolo. Pomaliza, nivolumab + fruquintinib (mankhwala oletsa angiogenic) adaperekedwa, koma osagwira ntchito bwino.
Pa tsiku la 28 la chithandizo cha CAR-T, chotupacho chinachepa ndi 47.3% poyerekeza ndi chithandizo chisanachitike, zomwe zinapangitsa kuti pakhale yankho lakuya (PR). Pofika tsiku la 60, chotupacho chinapitirira kuchepa ndi 41.9%, kusunga PR yotsimikizika, kusonyeza chithandizo chokhazikika komanso chogwira mtima.
Wodwala khansa ya m'mimba wazaka 55 adachitidwa opaleshoni ya laparoscopic radical gastrectomy mu Novembala 2023, pomwe matenda a postoperative adawonetsa adenocarcinoma yosiyana pang'ono ndi partinal signet-ring cell carcinoma (yoopsa kwambiri). Anayesa njira zingapo zochizira matenda a chemotherapy + immunotherapy, kuphatikizapo oxaliplatin + capecitabine + sintilimab, oxaliplatin + leucovorin + sintilimab, nab-paclitaxel + sintilimab + fruquintinib, ndi irinotecan monotherapy. Komabe, mu February 2025, vuto lake linakula mofulumira, zomwe zinapangitsa kuti chithandizo chamankhwala chisagwire ntchito.
Kenako adalandira chithandizo cha maselo a CAR-T, ndipo pofika tsiku la 28, chotupacho chinali chitachepa ndi 31.8% poyerekeza ndi chithandizo chisanachitike, zomwe zinapangitsa kuti pakhale yankho la pang'ono (PR), ndipo kuwongolera matenda kunatheka bwino.
Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.
Nambala ya Foni: 4008803716
Chizindikiro cha WeChat: 17801183037
Imelo：myimmnet@163.com
Nthawi yotumizira: Julayi-31-2025