Pa Ogasiti 22, 2025, Datopotamab deruxtecan (Dato-DXd; Datroway) yavomerezedwa ku China kuti ichite chithandizo cha odwala akuluakulu omwe ali ndi khansa ya m'mawere ya HER2 (immunohistochemistry [IHC] 0, IHC 1+, kapena IHC 2+/in situ hybridization [ISH] negative) omwe adalandirapo chithandizo cha endocrine komanso osachepera mzere umodzi wa chemotherapy pamlingo wapamwamba.
Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.
Nambala ya Foni: 4008803716
Chizindikiro cha WeChat: 17801183037
Email：myimmnet@163.com
Kuvomerezedwa kumeneku kumachokera ku zotsatira zabwino za kafukufuku wapadziko lonse wa Gawo III la TROPION-Breast01. Kafukufuku wapadziko lonse wa gawo lachitatu, wotseguka, wosasankhidwa wa TROPION-Breast01 adawunika trophoblast cell surface antigen 2-directed antibody-drug conjugate datopotamab deruxtecan (Dato-DXd) motsutsana ndi chisankho cha wofufuza cha chemotherapy (ICC) mu khansa ya m'mawere ya hormone receptor–positive/human epidermal growth factor receptor 2–negative (HR+/HER2–).
Odwala adapatsidwa mwachisawawa ku Dato-DXd (n = 365) kapena ICC (n = 367). Dato-DXd idachepetsa kwambiri chiopsezo cha kupita patsogolo kapena kufa poyerekeza ndi ICC (PFS by BICR hazard ratio [HR], 0.63 [95% CI, 0.52 mpaka 0.76]; P < .0001). Phindu lokhazikika la PFS lidawonedwa m'magulu ang'onoang'ono. Ngakhale deta ya OS sinali yokhwima, chizolowezi chokonda Dato-DXd chidawonedwa (HR, 0.84 [95% CI, 0.62 mpaka 1.14]). Chiŵerengero cha zochitika zoyipa zokhudzana ndi chithandizo (TRAEs) cha kalasi ≥3 ndi Dato-DXd chinali chotsika kuposa ICC (20.8% v 44.7%). Ma TRAE ofala kwambiri (giredi iliyonse; giredi ≥3) anali nseru (51.1%; 1.4%) ndi stomatitis (50%; 6.4%) ndi Dato-DXd ndi neutropenia (ma grouped term, 42.5%; 30.8%) ndi ICC.
Odwala omwe adalandira Dato-DXd anali ndi kusintha kwakukulu komanso kofunikira pazachipatala mu PFS komanso mbiri yabwino komanso yotetezeka, poyerekeza ndi ICC.
Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.
Nambala ya Foni: 4008803716
Chizindikiro cha WeChat: 17801183037
Email：myimmnet@163.com
Nthawi yotumizira: Ogasiti-26-2025