Pa February 13, 2026, Center for Drug Evaluation (CDE) ya China's National Medical Products Administration idalengeza kuti mapiritsi a GFH375 aphatikizidwa mu Breakthrough Therapy Designation pochiza odwala omwe ali ndi khansa ya m'mapapo ya KRAS G12D-mutant non-small cell lung cancer (NSCLC) omwe adalandira chithandizo chimodzi cham'mbuyomu.
Kuphwanya Malamulo a Cholinga "Chosagwiritsidwa Ntchito Molakwika"
Kale madokotala ankaona kusintha kwa KRAS ngati cholinga "chosagwiritsidwa ntchito mankhwala". Komabe, ndi kupita patsogolo kwa kafukufuku wa sayansi, vutoli likuthetsedwa pang'onopang'ono. KRAS G12D ndi imodzi mwa mitundu yodziwika bwino ya kusintha kwa KRAS, yomwe imapezeka kawirikawiri mu pancreatic ductal adenocarcinoma (PDAC), khansa ya m'mapapo yopanda maselo ang'onoang'ono (NSCLC), ndi khansa ya m'matumbo.
Kulimbikitsa Deta Yachipatala: GFH375 Ikuwonetsa Ntchito Yamphamvu Yolimbana ndi Chotupa
Deta yachipatala kuchokera ku mayeso a Gawo Loyamba la GFH375 mwa odwala omwe ali ndi zotupa zolimba za KRAS G12D-mutant, zomwe zidaperekedwa pa Msonkhano Wapachaka wa 2025 wa American Society of Clinical Oncology (ASCO), zidapereka zotsatira zolimbikitsa. Detayo idawonetsa kupezeka bwino kwa pakamwa komanso ntchito yosankha bwino yoletsa zotupa za GFH375. Pofika tsiku lomaliza la deta, odwala 62 omwe anali ndi zotupa zolimba za KRAS G12D-mutant zomwe zidachiritsidwa kale adalembetsedwa mu mayeso a Gawo Loyamba la GFH375 monotherapy.
Magulu a Target Dose: Kugwira Ntchito Kodziwika Kwambiri
Mwa odwala 49 omwe amalandira mlingo wa 400mg kapena 600mg patsiku, deta yogwira ntchito inali yodabwitsa kwambiri:
Chiŵerengero Chonse Choyankha Cholinga (ORR): Mwa odwala 43 omwe adayesedwa, ORR idafika pa 42%, ndipo Chiŵerengero Chowongolera Matenda (DCR) chinali chokwera kufika pa 91%.
Odwala Pancreatic Ductal Adenocarcinoma (PDAC): Pakati pa odwala 23 omwe adayesedwa a PDAC, ORR inali 52%, ndipo DCR idafika 100%.
Odwala Khansa ya M'mapapo Yosakhala Yaing'ono (NSCLC): Pakati pa odwala 12 a NSCLC omwe amayesedwa, ORR inali 42%, ndipo DCR inali 83%.
Magulu Onse a Mlingo: Ntchito Yaikulu komanso Yofunika Kwambiri
Mwa odwala 52 omwe adamaliza kuwunika kamodzi kokha pambuyo pa chithandizo cha chotupa, ORR m'magulu onse a mlingo inali 38%, ndi DCR ya 90%. Chodziwika bwino n'chakuti, odwala 38 adachepetsa zilonda zomwe adawafuna, ndipo odwala 20 adapeza yankho pang'ono. Deta yoyambayi ikuwonetsa kuti GFH375 ikuwonetsa ntchito yayikulu yoletsa chotupa mwa odwala omwe ali ndi zotupa zolimba monga PDAC ndi NSCLC, kuphatikiza omwe adapita patsogolo pambuyo pa njira zingapo zochiritsira.
Poyang'anizana ndi kupita patsogolo kwamakono kwa zamankhwala, kusankha chipatala chomwe chingathe kupereka njira zamakono zochiritsira komanso ntchito zambiri ndikofunikira kwambiri. Dipatimenti Yapadziko Lonse ku Beijing South Region Oncology Hospital yadzipereka kupereka chithandizo chamakono chozindikira khansa komanso chithandizo kwa odwala am'deralo komanso akunja. Timakhala ndi chidziwitso chaposachedwa cha kafukufuku wapadziko lonse wa khansa ndipo tadzipereka kubweretsa njira zatsopano zochiritsira monga GFH375 kwa odwala omwe akufunika thandizo mwachangu momwe tingathere.
Ubwino wathu ndi monga:
Mayankho Achipatala Apamwamba: Tikutsatira miyezo yapadziko lonse lapansi, kuyang'ana kwambiri ndikuyambitsa njira zamakono zochizira kuphatikizapo GFH375, kupereka mwayi wochiritsira odwala omwe ali ndi kusintha kwa KRAS G12D.
Gulu la Akatswiri Osiyanasiyana: Timabweretsa pamodzi akatswiri apamwamba a khansa m'dziko lathu omwe amagwira ntchito limodzi popereka upangiri kwa odwala osiyanasiyana kuti apange mapulani olondola komanso olondola a chithandizo cha wodwala aliyense.
Miyezo Yogwira Ntchito Padziko Lonse: Kuyambira kufunsira upangiri, kukonza nthawi yokumana, ntchito zomasulira mpaka njira yonse yothandizira, timapereka kulankhulana bwino komanso chithandizo chosamala, kuonetsetsa kuti odwala ochokera kumayiko ena ndi mabanja awo ali ndi chithandizo chabwino komanso cholimbikitsa.
Chithandizo Chokwanira cha Odwala: Timayesetsa kuchita bwino kwambiri osati kokha pa chithandizo komanso kuyang'ana kwambiri thanzi la odwala m'maganizo komanso moyo wabwino, popereka chithandizo ndi chisamaliro.
Lumikizanani nafe Tsopano kuti mudziwe chiyembekezo chatsopano cha chithandizo
Ngati inu kapena wachibale wanu mwapezeka ndi khansa ya m'mapapo ya KRAS G12D-mutant non-small cell lung cancer kapena zotupa zina zolimba ndipo simunayankhe bwino njira zomwe zilipo kale zochiritsira, chonde lemberani Dipatimenti Yapadziko Lonse ku Beijing South Region Oncology Hospital. Gulu lathu la akatswiri lidzakupatsani zambiri zachipatala zaposachedwa komanso malangizo amomwe mungadziwire matenda ndi chithandizo.
Chonde titumizireni uthenga kudzera m'njira zotsatirazi:
Foni: 400-880-3716
WeChat: 17801183037
Email: 100085_010@163.com 或 myimmnet@163.com
Musalole kuti mtunda kapena zopinga za chilankhulo zikhale zopinga pakufunafuna chithandizo chapamwamba. Dipatimenti Yapadziko Lonse ku Beijing South Region Oncology Hospital ili pano kuti ikuthandizeni polimbana ndi khansa.
Nthawi yotumizira: Feb-25-2026