Lipoti la Nkhani Yokhudza Kuyankha Kwathunthu Kwa Nthawi Yaitali mu Hepatocellular Carcinoma ku GPC3 CAR T Cells (CT011)

CT011 ndi mankhwala a GPC3 CAR T-cell omwe amagwiritsidwa ntchito pochiza khansa ya chiwindi (HCC). CT011 idalandira chilolezo cha IND kuchokera ku NMPA mu 2019 kuti ichiritse odwala omwe ali ndi chotupa cholimba cha GPC3-positive chomwe chinali chilolezo choyamba cha IND ku China cha chithandizo cha maselo a CAR T motsutsana ndi zotupa zolimba.

Pa Ogasiti 18, 2022, CARsgen Therapeutics yalengeza kuti lipoti la mlandu, lotchedwa "Long Term Term Complete Response of Advanced Hepatocellular Carcinoma to Glypican-3 Specific Chimeric Antigen Receptor T-Cells plus Sorafenib, lipoti la mlandu", lafalitsidwa mu Frontiers in Immunology.

Mlanduwu unasonyeza wodwala wamwamuna wazaka 60 waku Asia yemwe ali ndi HCC yokhudzana ndi kachilombo ka hepatitis B (HBV) yemwe adachitidwa opaleshoni mu Meyi 2018. Mu Ogasiti 2018, khansa ya chiwindi ndi kufalikira kwa pulmonary kunachitika pambuyo pa opaleshoni, kenako adalandira transarterial chemoembolization (TACE) kuti achiritse zilonda za chiwindi ndi kuchotsedwa kwa pulmonary metastases. Patatha miyezi iwiri, adapita patsogolo ndipo adalembetsedwa mu mayeso azachipatala. Pambuyo polembetsa, wodwalayo adachitidwa leukapheresis kuti apange maselo a CAR-GPC3 T. Patatha masiku asanu ndi awiri leukapheresis itatha, wodwalayo adayamba kulandira 400 mg ya sorafenib kawiri patsiku. Wodwalayo adalandira ma cycle anayi a CAR-GPC3 T cells (CT011) ndipo cycle iliyonse idagawidwa m'ma infusions awiri. Asanayambe CT011, lymphodepletion idachitika. Chiwerengero chonse cha 4×10⁹Maselo a T a CAR-GPC3 adalowetsedwa.

Chithandizo chophatikiza cha CT011 pamodzi ndi sorafenib chinali chovomerezeka bwino. Wodwalayu adalandira mayankho osakwanira (PR) kuyambira mwezi wachitatu ndipo adapeza CR m'mwezi wa 12 pambuyo pa nthawi yoyamba ya CT011. Chotupacho sichinapitirire kwa miyezi yoposa 36 ndipo chinakhalabe ndi CR kwa miyezi yoposa 24 pambuyo pa nthawi yoyamba ya CT011.

Monga momwe tikudziwira, uwu ndi mlandu woyamba wonenedwa wa CR pambuyo pa chithandizo chophatikizana cha maselo a CAR T ndi zoletsa za tyrosine kinase. Zotsatira zachipatala zasonyeza kuti chithandizo chophatikizana cha maselo a GPC3 CAR T ndi Sorafenib chikhoza kukhala njira yatsopano yodalirika kwa odwala a HCC apamwamba a GPC3+.

Pakadali pano, pali mayeso ena ambiri azachipatala a CAR-T ku China, ndipo akufunafuna odwala. Kuti mumve zambiri za mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.

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