Wodwala khansa ya muubongo yemwe anali atachira matenda ake kwa miyezi yoposa 20, yemwe anabwereranso ku matenda ake atalandira chithandizo cha CAR-T kwa nthawi 17, chotupa chake chinatha kwathunthu mkati mwa milungu inayi atalandira chithandizo chatsopano cha TIL ndipo wakhalabe wopanda chotupa kwa miyezi yoposa 20.
Kuti mudziwe zambiri zokhudza mankhwala atsopano a khansa ndi mayesero azachipatala:
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Wodwala wamwamuna wazaka 56 anapezeka ndi matenda a glioblastoma (IDH wild-type, WHO Giredi 4, EGFR amplification)—imodzi mwa mitundu yoopsa kwambiri komanso yovuta kuchiza ya glioma ya ubongo.
Atachitidwa opaleshoni yochotsa chotupa pa Januware 5, 2023, poyamba adalandira chithandizo chokhazikika, koma vuto lake linabwereranso patatha nthawi yochepa yokhazikika. Pambuyo pake, adalandira chithandizo cha CAR-T chokwana 17 chokhudzana ndi ma antigen awiri osiyana, koma matenda ake adapitilirabe.
Posowa chochita, analembetsa mu mayeso azachipatala kuti apeze chithandizo chatsopano cha TIL. Zotsatira zake zinali zodabwitsa: patangopita milungu inayi kuchokera pamene anapatsidwa TIL cell, kuyezetsa zithunzi kunasonyeza kuti chotupa muubongo mwake chinali chitachotsedwa kwathunthu, zomwe zinamuthandiza kuti ayankhe bwino, ndipo wakhalabe wopanda chotupa kwa miyezi yoposa 20.
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Kulimbana Kuti Tipulumuke Mu Mkhalidwe Wovuta
Glioblastoma imadziwika kuti ndi "wakupha wamkulu kwambiri mkati mwa mutu." Nthawi yodziwira matendawa imamveka ngati kuyamba kwa kuwerengera nthawi ya moyo.
Pambuyo poti a W apezeka ndi matendawa, choyamba adachitidwa opaleshoni yochotsa khansa ya muubongo yomwe inali yoopsa kwambiri, kenako adapatsidwa mankhwala a chemotherapy a temozolomide ndi radiotherapy. Komabe, vuto lake silinathe kuthetsedwa.
Pambuyo pake, anayesa njira ziwiri zosiyana za CAR-T zokhudzana ndi ma antigen osiyanasiyana, kulandira jakisoni wopitilira 10 mkati mwa chotupa nthawi zonse, koma izi sizinalepheretse kufalikira kwa chotupa.
Mankhwala achikhalidwe sagwira ntchito bwino pochiza matenda a glioma ya ubongo. Ngakhale ndi mapulani ophatikizana a chithandizo chokhudza opaleshoni, radiotherapy, ndi chemotherapy, apakati a moyo wa odwala ndi miyezi 14.6 yokha.
Pokumana ndi vuto lotere, a W ndi banja lawo adataya mtima kwambiri mpaka atadziwa za mayeso azachipatala a TIL therapy.
Chithandizo cha TIL
Chithandizo cha TIL, kapena chithandizo cha Tumor-Infiltrating Lymphocyte, ndi njira yatsopano yochizira matenda a m'thupi.
Chithandizochi chimayamba ndi minofu yatsopano ya chotupa cha wodwalayo ngati chinthu choyamba. Pambuyo poika maselo m'thupi, kuwasintha, ndi kuwakulitsa mu vitro, maselowo amabwezeretsedwanso mwa wodwalayo, zomwe zimapangitsa kuti alandire chithandizo choyenera chomwe "chimalimbana ndi chotupacho chokha."
Mosiyana ndi chithandizo chachikhalidwe cha CAR-T, chithandizo cha GC101 TIL sichifuna jakisoni wa lymphodepletion kapena jakisoni wa IL-2, zomwe zimapangitsa kuti chitetezo cha chithandizocho chikhale chosavuta komanso chosavuta.
Yopangidwa ndi Juncell Therapeutics, GC101 TIL therapy ndi njira yoyamba yachilengedwe padziko lonse ya TIL yomwe siifuna lymphodepletion kapena jakisoni wa IL-2, pogwiritsa ntchito nsanja yake yokulitsa maselo a DeepTIL® yomwe idapangidwa yokha.
Deta yachipatala yomwe ilipo ikuwonetsa kuti GC101 ili ndi chiŵerengero cha mayankho olondola choposa 35% motsutsana ndi mitundu yosiyanasiyana ya zotupa zolimba. Odwala angapo akwanitsa kuchotsa chotupa kwathunthu komanso kuyankha kwathunthu, ndipo nthawi yayitali kwambiri yopanda chotupa imaposa zaka zitatu.
Njira Yothandizira
Kumapeto kwa chaka cha 2023, a W adalembetsa bwino mu mayeso azachipatala a GC101 TIL.
Gulu lachipatala linagwiritsa ntchito maselo a TIL omwe adamera kuchokera ku chitsanzo chake cha opaleshoni chomwe adachipeza chaka chapitacho, chomwe chidasungidwa mpaka pakufunika.
Gulu lothandizira linakulitsa bwino maselowo kufika pa maselo onse a 2.95 × 10^10 TIL, ndipo maselo a T ndi omwe ali ndi 99.92% ya anthu, makamaka maselo a CD8⁺ T (97.85%).
Pambuyo pokonza bwino, a W adalandira chithandizo cha TIL cell pa Disembala 12, 2023.
Pa nthawi yomwe ankapatsidwa mankhwala oletsa kutupa, a W sanakumane ndi vuto lililonse, koma malungo ochepa okha ndi omwe anatha msanga. Poyerekeza ndi mankhwala achikhalidwe a TIL, mtundu wosinthidwawu unawonetsa chitetezo chapamwamba.
Kusintha Kodabwitsa
Patangopita milungu inayi yokha kuchokera pamene maselo a TIL adalowetsedwa, mayeso ojambulira zithunzi pa Januwale 8, 2024, adawonetsa kuti chotupa muubongo wa a W chinali chitachotsedwa kwathunthu.
Chodabwitsa kwambiri n'chakuti, kuyambira mu Okutobala 2025, wodwalayo wakhalabe ndi moyo wopanda chotupa kwa zaka zoposa 1.8 (zowerengedwa panthawi yofalitsa nkhani, izi ndi miyezi yoposa 20), akubwerera ku moyo wabwinobwino.
Mlanduwu ukukhazikitsa mbiri yatsopano yopulumuka matenda a glioblastoma obwerezabwereza ndipo umapereka umboni wofunikira wachipatala pa njira yothandizira "kuyesa minofu koyambirira, kubwezeretsanso TIL pakubwereranso."
Kupambana kwakukulu kumeneku kudzawonetsedwa mu positi pa Msonkhano Wapachaka wa 40 wa Society for Immunotherapy of Cancer, womwe udzachitike kuyambira pa 7-9 Novembala, 2025, ndikuwuwonetsa kwa akatswiri apadziko lonse lapansi.
Ziyembekezo za M'tsogolo
Chithandizo cha TIL chawonetsa kuthekera osati kokha pa chithandizo cha glioma ya ubongo komanso chawonetsa mphamvu yodabwitsa polimbana ndi zotupa zina zolimba monga khansa ya melanoma yotsogola komanso khansa ya m'mapapo yopanda maselo ang'onoang'ono.
Mu February 2024, chithandizo choyamba cha TIL cell therapy padziko lonse, Lifileucel, chinavomerezedwa ndi FDA ku United States chifukwa chochiza odwala omwe ali ndi melanoma yapamwamba omwe adalandira kale chithandizo cha PD-1 inhibitor.
Pa nthawi yomweyo, China ikupitilizabe kufufuza zachipatala pa chithandizo cha TIL. Mayeso ofunikira kwambiri olembetsa a Gawo Lachiwiri a Juncell Therapeutics's GC101 TIL jakisoni yolimbana ndi melanoma yapamwamba avomerezedwa ndi Center for Drug Evaluation of the National Medical Products Administration.
Kuphatikiza apo, pa Okutobala 14, 2024, mayeso oyamba olembetsa mankhwala a TIL cell ku China makamaka khansa ya m'mapapo adayambitsidwa mwalamulo, cholinga chake chinali kuchiza khansa ya m'mapapo yosakhala yaing'ono.
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Pakadali pano, pali mayesero ambiri azachipatala okhudza mankhwala atsopano oletsa khansa komanso ukadaulo ku China wofunafuna odwala.
Dipatimenti ya Chipatala cha Oncology cha Beijing South Region International ikupereka upangiri pa mankhwala ndi ukadaulo watsopano.
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Nthawi yotumizira: Novembala-20-2025