Posachedwapa, kafukufuku wa Antengene's Phase I/II CLINCH wa ATG-022 (CLDN18.2 antibody-drug conjugate), wodwala wokalamba yemwe ali ndi khansa ya m'mimba yopita patsogolo yemwe wapita patsogolo pa njira zingapo za chemotherapy, immunotherapy ndi chithandizo cholunjika ngakhale kuti metastases yayikulu yapezeka ndi yankho lathunthu (CR) pambuyo pa ATG-022 monotherapy. Mkhalidwe wopanda chotupa wa wodwalayo unatsimikiziridwa ndi PET/CT mu Meyi 2025.
Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.
Nambala ya Foni: 4008803716
Chizindikiro cha WeChat: 17801183037
Email：myimmnet@163.com
ATG-022 ndi CLDN18.2 ADC yomwe inapezedwa ndi kupangidwa mkati ndi Antengene. Pa msonkhano wa ASCO GI 2025 koyambirira kwa chaka chino, Antengene inapereka deta yatsopano yachipatala ya ATG-022. Kwa odwala omwe ali ndi CLDN18.2 expression yocheperako mpaka yapamwamba (IHC 2+ ≥ 20%), chiŵerengero cha yankho lolunjika (ORR) chinali 42.9%, ndipo chiŵerengero chowongolera matenda (DCR) chinali 95.2%. Pakati pa odwala omwe ali ndi CLDN18.2 expression yotsika (IHC 2+ < 20%), ORR inali 30.0%, ndipo DCR inali 50.0%. Deta iyi ikuwonetsa kuti ATG-022 imapereka mphamvu yothandiza kuchipatala komanso chitetezo chabwino pamlingo wosiyanasiyana wa CLDN18.2 expression, kuphatikizapo expression yapamwamba, yotsika, komanso yotsika kwambiri. Ntchito yake yolimbana ndi chotupa cha m'magazi ikusonyeza kuti ATG-022 ikhoza kupereka maubwino ochizira kwa odwala ambiri poyerekeza ndi mankhwala ena omwe amagwiritsidwa ntchito ndi CLDN18.2. Pakadali pano, kafukufuku wokulitsa mlingo wa ATG-022 wa Gawo Lachiwiri ukupitilira ku China ndi Australia.
Kupambana kwa CR mwa wodwala khansa ya m'mimba wokalambayu ndikolimbikitsa kwambiri, kukuwonetsa kuthekera kwa ATG-022 kuchiza ngati chithandizo chatsopano cha ADC. Chofunika kwambiri, ichi si CR yokhayo yomwe yawonedwa mu kafukufukuyu. Mpaka pano, milandu itatu ya CR yawonedwa, kuphatikiza odwala ochokera ku China ndi Australia. Antengene ikuyembekezera kupereka zambiri zatsopano kuchokera ku kafukufuku wa ATG-022 pa Msonkhano wa ESMO womwe ukubwera mu Okutobala 2025.
Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.
Nambala ya Foni: 4008803716
Chizindikiro cha WeChat: 17801183037
Email：myimmnet@163.com
Nthawi yotumizira: Ogasiti-21-2025