Mu 2021, wodwala khansa ya kapamba wazaka 67 adapanga chozizwitsa chachipatala. Atachitidwa opaleshoni, kulandira mankhwala a chemotherapy nthawi zambiri, komanso kulephera kwa chithandizo cha TIL, mayeso azachipatala a TCR-T adachitika.Chithandizo cha maselo chomwe adachita nawo chinapangitsa kuti matenda a m'mapapo achepe ndi 72% mkati mwa miyezi 6. Zotsatira zake zopambana zinasindikizidwa mu New England Journal of Medicine, zomwe zinabweretsa chiyembekezo chatsopano kwa odwala omwe ali ndi zotupa zolimba padziko lonse lapansi.
Chipatala cha International Consultation Center cha Beijing South Suburb Oncology Hospital (400 – 880 – 3716) chingamange mlatho wopita kuchipatala chapamwamba cha padziko lonse kwa odwala chifukwa cha chuma chake chapadziko lonse lapansi ndipo chimagwira ntchito yofunika kwambiri pakupereka uphungu ndi chithandizo chamankhwala padziko lonse lapansi.
Zokhudza TCR-TChithandizo
TCR-TChithandizo cha maselo, chomwe dzina lake lonse ndi T – cell receptor engineered T – cell therapy, ndi njira yatsopano yolandirira chitetezo cha mthupi cha maselo. Mfundo yake yaikulu ndikutulutsa maselo a T m'thupi la wodwalayo ndikuyambitsa jini ya TCR yomwe imatha kuzindikira ma antigen enaake a chotupa mu maselo a T kudzera muukadaulo wa majini. Zotsatira zake, maselo a T osinthidwa amatha kuzindikira molondola ndikumangirira ku ma antigen pamwamba pa maselo a chotupa, motero kuyambitsa ntchito yopha chitetezo cha mthupi ya maselo a T ndikukwaniritsa cholinga chochotsa maselo a chotupa.
Nkhani Yopambana ya TCR-TChithandizo: Chozizwitsa cha Wodwala ndi KRAS G12D - Khansa ya Pancreatic Yosinthika
Asanapezeke ndi pancreatic head adenocarcinoma, wodwalayo wazaka 67 uyu adavutika kwambiri chifukwa cha matenda obwerezabwereza a kapamba komanso biliary stricture. Atapezeka ndi matendawa, adachitidwa opaleshoni ya FOLFIRINOX neoadjuvant chemotherapy regimen kanayi, kenako adachitidwa opaleshoni yochotsa khansa kenako ndi mankhwala ena a chemotherapy. Izi zidathandiza kuti vuto lake lithe kuthetsedwa kwa nthawi inayake, ndipo chotupacho sichinapitirire.
Komabe, nthawi yabwinoyi sinatenge nthawi yayitali. Mu 2019, wodwalayo adayamba kudwala matenda a m'mapapo, zomwe mosakayikira zidabweretsa vuto lalikulu pa chithandizocho. Mu 2020, adachita nawo mayeso azachipatala a chotupa - chithandizo cholowa m'magazi, koma patatha miyezi isanu ndi umodzi, zilonda za m'mapapo zidayambiranso, zomwe zikusonyeza kuti njira zamankhwala zam'mbuyomu sizingathenso kuwongolera bwino kukula kwa chotupacho.
Pamene wodwalayo anali pafupi kutaya mtima, mu Meyi 2021, bungwe la US Food and Drug Administration linavomereza pulogalamu yatsopano yofufuza mankhwala, yomwe inakhala nthawi yofunika kwambiri pa moyo wake - adadziwitsidwa za TCR-T.chithandizo cha maselo. Mu June 2021, adalandira chithandizo cha maselo a T m'magazi a autologous. Chodabwitsa n'chakuti, mwezi umodzi pambuyo poti maselo alowetsedwa, zilonda za m'mapapo a wodwalayo zinachepa kwambiri, ndipo chotupacho chinachepa ndi 62%. Patatha theka la chaka, chotupacho chinachepa ndi 72%.
Mphamvu yodabwitsa iyi yochiritsira ikuwonetsa bwino kuthekera kwakukulu kwa TCR-Tchithandizo cha maselo pochiza khansa.
Kwa odwala khansa, kupeza matenda olondola komanso njira yabwino kwambiri yothandizira n'kofunika kwambiri. Komabe, chifukwa cha kusiyana kwa milingo ya zamankhwala ndi ukadaulo m'madera osiyanasiyana, odwala sangathe kupeza upangiri wapamwamba kwambiri wa chithandizo m'deralo. Kukambirana kwapadziko lonse kumapatsa odwala mwayi wolankhulana ndi akatswiri apamwamba apadziko lonse lapansi, zomwe zimawathandiza kuphunzira za njira zamakono zochiritsira komanso zotsatira za kafukufuku padziko lonse lapansi.
Kudzera mu uphungu wapadziko lonse, odwala amatha kulandira kuwunika kosiyanasiyana kuchokera kwa akatswiri ochokera m'maiko ndi madera osiyanasiyana. Akatswiriwa ali ndi chidziwitso chambiri pazachipatala komanso chidziwitso chaukadaulo ndipo amatha kusanthula ndikuweruza matenda a wodwalayo kuchokera m'njira zosiyanasiyana kuti apange mapulani ochiritsira omwe ali ndi makonda awo komanso olondola.
Kuphatikiza apo, kukambirana ndi mayiko ena kungathandizenso odwala kudziwa za mayeso ena azachipatala ndi njira zochiritsira zomwe sizinachitikebe ku China, zomwe zingawapatse njira zina zochiritsira.
Chipatala cha International Department of Beijing South Suburb Oncology Hospital (400 – 880 – 3716) chikudziwa bwino kufunika kwa uphungu wapadziko lonse kwa odwala khansa. Chifukwa chake, chimamanga mwachangu nsanja yosinthirana zamankhwala padziko lonse lapansi kuti ipatse odwala ntchito zofunsira zaukadaulo komanso zogwira mtima padziko lonse lapansi. Ku Chipatala cha International Department of Beijing South Suburb Oncology, odwala amatha kutenga nawo mbali pa uphungu wapadziko lonse lapansi pa intaneti kapena pa intaneti. Gulu lathu lachipatala lidzasonkhanitsa zolemba zachipatala za wodwalayo, malipoti a mayeso ndi zina zambiri pasadakhale ndikuzimasulira mu Chingerezi kuti zitsimikizire kuti akatswiri apadziko lonse lapansi athe kumvetsetsa bwino momwe wodwalayo alili. Pa nthawi yofunsira, akatswiri apadziko lonse lapansi adzalankhulana maso ndi maso ndi wodwalayo, kufunsa mafunso atsatanetsatane okhudza mbiri yachipatala ya wodwalayo, zizindikiro zake, ndi momwe chithandizo chake chilili, kenako kuphatikiza zotsatira zaposachedwa za kafukufuku wazachipatala komanso zomwe adakumana nazo kuchipatala kuti apange dongosolo loyenera kwambiri la chithandizo kwa wodwalayo.
Nthawi yomweyo, Chipatala cha International Department of Beijing South Suburb Oncology Hospital chidzapatsanso odwala ntchito zonse zomasulira ndi kugwirizanitsa kuti atsimikizire kuti uphungu ukuyenda bwino. Pambuyo pa uphungu, tidzapereka mwachangu zotsatira za uphungu ndi malingaliro a chithandizo kwa wodwalayo ndikupereka chitsogozo ndi chithandizo chotsatira chithandizo.
Pofuna kuthandiza odwala kupeza malingaliro a akatswiri apadziko lonse lapansi okhudza matenda ndi chithandizo mwachangu, Dipatimenti Yapadziko Lonse ya Beijing South Suburb Oncology Hospital yachepetsa njira yoperekera chithandizo. Odwala amangofunika kuyimba 400 - 880 - 3716 ndikupereka zolemba zachipatala zoyenera komanso malipoti oyesera. Gulu la akatswiri la Beijing South Suburb Oncology Hospital lidzakonza katswiri woyenera wapadziko lonse lapansi kuti wodwalayo akambirane naye mkati mwa nthawi yochepa kwambiri. Pa nthawi yopereka chithandizo, gulu la akatswiri omasulira lidzaonetsetsa kuti kulumikizana bwino komanso kolondola pakati pa madokotala ndi odwala, zomwe zimathandiza odwala kumvetsetsa bwino malingaliro ndi malingaliro a akatswiri. Kuphatikiza apo, Dipatimenti Yapadziko Lonse ya Beijing South Suburb Oncology Hospital ingathandizenso odwala kuthana ndi njira zotumizira odwala, kukonza maulendo, ndi zina zotero, kupereka chithandizo chimodzi chokha.
Kugawana Nkhani ndi Kudzoza
Kuwonjezera pa nkhani yomwe ili pamwambapa ya wodwala yemwe ali ndi khansa ya kapamba yosinthika ya KRAS G12D, Chipatala cha International Department of Beijing South Suburb Oncology Hospital chathandizanso odwala khansa ochokera kumayiko ena kupeza zotsatira zabwino za chithandizo chamankhwala kudzera mu chithandizo chamankhwala ku China.
Mu June 2024, wodwala khansa ya m'mapapo yosakhala ya maselo ang'onoang'ono ochokera ku North Korea anapempha thandizo kwa ife. Khansa ya m'mapapo ndi imodzi mwa zotupa zoopsa zomwe zili ndi kuchuluka kwakukulu kwa matendawa padziko lonse lapansi komanso ku China. Mu 2022, panali milandu yatsopano pafupifupi 1.06 miliyoni ndipo anthu pafupifupi 740,000 anamwalira chifukwa cha khansa ya m'mapapo ku China, pakati pawo khansa ya m'mapapo yosakhala ya maselo ang'onoang'ono (NSCLC) ndi pafupifupi 80% - 85%.
Wodwalayo anali ndi kusintha kwa EGFR ndipo analandira chithandizo monga afatinib ndi osimertinib. Ngakhale kuti analandira chithandizo chosiyanasiyana, nkhani zoipa zinabwerabe mu Meyi 2024, ndipo matenda a wodwalayo anakula. Choncho anabwera ku China kuti atithandize.
Pambuyo poyesa, mawonekedwe a mesothelin (MSLN) a wodwalayo anali 75%. Kenako tinathandiza wodwalayo kupeza njira yatsopano yothandizira m'dziko lonselo. Tsopano vuto la wodwalayo lachepa, ndipo timitsempha ta m'mapapo tachepa, monga momwe chithunzi chili pansipa chikusonyezera.
Nkhaniyi ikutiuza kuti kwa odwala khansa, sayenera kusiya mosavuta mwayi wopeza chithandizo. Ngakhale chithandizo cha m'nyumba chili chovuta, amathanso kumvetsetsa njira zamakono zamankhwala apadziko lonse lapansi komanso zotsatira za kafukufuku kudzera mu upangiri wapadziko lonse lapansi ndikuyesetsa kupeza mwayi wochulukirapo wopezera chithandizo.
Momwe Mungalankhulire ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Suburb
Ngati inu kapena achibale anu mukudwala khansa ndipo mukuyembekeza kuphunzira za njira zamakono zochizira matenda padziko lonse lapansi kapena kupeza malingaliro a akatswiri apadziko lonse lapansi okhudza matenda ndi chithandizo, chonde imbani nambala ya foni ya International Department of Beijing South Suburb Oncology Hospital (400 – 880 – 3716). Gulu la akatswiri lidzayankha mafunso anu, kukonza zokambirana zapadziko lonse lapansi, ndikukupatsani chithandizo ndi chithandizo chokwanira.
Chithandizo cha khansa ndi nkhondo yayitali komanso yovuta, koma tikukhulupirira kuti ndi kupita patsogolo kosalekeza kwa ukadaulo wazachipatala, odwala khansa ambiri adzatha kuthana ndi matendawa ndikuchira thanzi lawo. Chipatala cha International Department of Beijing South Suburb Oncology Hospital chipitiliza kuyesetsa kupititsa patsogolo ntchito zake zachipatala komanso luso lake lachipatala ndikupereka chithandizo chamankhwala chapamwamba kwambiri padziko lonse lapansi kwa odwala khansa ambiri. Tiyeni tigwire ntchito limodzi kuti tithane ndi khansa ndikupanga zodabwitsa za moyo!
Pakadali pano, pali mayesero ambiri azachipatala a ukadaulo watsopano wothana ndi khansa ku China omwe akufuna odwala. Mukafunsira mankhwala ndi ukadaulo watsopano, mutha kulumikizana ndi Dipatimenti Yapadziko Lonse ya Chipatala cha Oncology ku Beijing South Region.
Nambala ya Foni: 4008803716
Email：myimmnet@163.com
Nthawi yotumizira: Meyi-15-2025