Hyperthermia for Tumor Ablation: Pancreatic Cancer's Treatment Case and Research

Khansa ya kapamba ali ndi matenda owopsa kwambiri komanso osadziwika bwino.Muzochita zachipatala, odwala ambiri amapezeka pa siteji yapamwamba, ndi otsika kwambiri opangira opaleshoni ndipo palibe njira zina zapadera zothandizira.Kugwiritsa ntchito HIFU kumatha kuchepetsa chotupa, kuwongolera ululu, potero kumatalikitsa moyo wa odwala ndikuwongolera moyo wabwino.

Mbiri ya Hyperthermiachifukwa zotupa zimatha kutsatiridwazaka 5,000 zapitazoku Egypt wakale, wokhala ndi zolembedwa m'mipukutu yakale yaku Egypt yofotokoza kugwiritsa ntchitokutentha kuchiza zotupa za m'mawere.Woyambitsa wamatenthedwe mankhwala, Hippocrates, yemwe amadziwika kuti ndi tate wa mankhwala a Azungu, anakhalako zaka pafupifupi 2,500 zapitazo.

Hyperthermia ndi njira yochizira yomwe imaphatikizapo kugwiritsa ntchito magwero osiyanasiyana otentha(monga ma radiofrequency, microwave, ultrasound, laser, etc.)kuonjezera kutentha kwa chotupa minofu kuti ogwira achire mlingo.Kukwera kwa kutenthaku kumabweretsa kufa kwa maselo otupa pomwe kumachepetsa kuwonongeka kwa maselo abwinobwino.

Mu 1985, US FDA idatsimikizira opaleshoni, chithandizo cha radiation, chemotherapy, Hyperthermia, ndi immunotherapy mongawachisanu ogwira njira mankhwala chotupa, kuyimira njira yatsopano komanso yothandiza.

Mfundo yofunika kwambiri ndikugwiritsa ntchito mphamvu zolimbitsa thupi kutenthetsa thupi lonse kapena gawo linalake la thupi, kukweza kutentha kwa minofu ya chotupa kuti ikhale yothandiza kwambiri ndikuyisunga kwa nthawi yayitali.Pogwiritsa ntchito kusiyana kwa kulolerana kwa kutentha pakati pa minofu yachibadwa ndi maselo otupa, cholinga chake ndi kukwaniritsa cholinga choyambitsa chotupa cell apoptosis popanda kuwononga minofu yachibadwa.

Chithandizo cha Khansa ya Pancreatic 1:

Wodwala: Mkazi, wazaka 46, chotupa mumchira wa kapamba

Kutalika kwa chotupacho ndi 34mm (anteroposterior), 39mm (transverse), ndi 25mm (craniocaudal).Pambuyo pa ultrasound-guided thermal ablation therapy,MRI yotsatira idawulula kuti chotupa chochulukacho chinali chosagwira ntchito.

Chithandizo cha Khansa ya Pancreatic 2:

Wodwala: Mkazi, wazaka 56, khansa ya pancreatic yokhala ndi metastases yambiri ya chiwindi

Kuchiza munthawi yomweyo kwa kapamba ndi chiwindi metastases pogwiritsa ntchito ultrasound-guided thermal ablation therapy.MRI yotsatila idawonetsa chotupa chosagwira ntchito, chokhala ndi malire omveka bwino komanso olondola.

Chithandizo cha Khansa ya Pancreatic 3:

Wodwala: Mwamuna, wazaka 54, khansa ya pancreatic

Ululu kwathunthu anamasuka mkati 2 masikupambuyo pa chithandizo cha HIFU (high-intensity focused ultrasound).Chotupacho chinachepa ndi 62.6% pa masabata 6, 90.1% pa miyezi itatu, ndipo milingo ya CA199 inabwerera mwakale pa miyezi 12.

Chithandizo cha Khansa ya Pancreatic Mlandu 4:

Wodwala: Mkazi, wazaka 57, khansa ya pancreatic

Chotupa necrosis zinachitika 3 patatha masiku HIFU mankhwala.Chotupacho chinachepa ndi 28.7% pa masabata 6, 66% pa miyezi 3, ndipo ululu unatha.

Chithandizo cha Khansa ya Pancreatic Mlandu 5:

Wodwala: Mkazi, wazaka 41, khansa ya pancreatic

Pambuyo masiku 9 a chithandizo cha HIFU,kuwunika kwa PET-CT kunawonetsa necrosis yayikulu pakatikati pa chotupacho.

Chithandizo cha Khansa ya Pancreatic Mlandu 6:

Wodwala: Mwamuna, wazaka 69, khansa ya pancreatic

Kutsata kwa PET-CT scan theka la mwezi pambuyo pa chithandizo cha HIFUanaulula wathunthu kuzimiririka kwa chotupacho, palibe kutengeka kwa FDG, ndi kutsika kotsatira kwa milingo ya CA199.

Chithandizo cha Khansa ya Pancreatic 7:

Wodwala: Mkazi, wazaka 56, khansa ya pancreatic

CT scan yotsatila tsiku limodzi chithandizo cha HIFU chitatha80% kuchotsa chotupa.

Chithandizo cha Khansa ya Pancreatic Mlandu 8:

Zaka 57, khansa ya pancreatic

Pambuyo pa chithandizo cha HIFU, CT scan yotsatilaanawulula ablation wathunthu pakati pa chotupacho.